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Gastroenterology Clinics of North America | March 2020

Authors: Manu V. Chakravarthy MD, PhD, Thomas Waddell MS, Rajarshi Banerjee BMBCh, MRCP, DPhil, Nicola Guess RD, MPH, PhD


  • Nonalcoholic fatty liver disease (NAFLD) pathogenesis and progression are complex, heterogeneous, and multifactorial.
  • The human diet typically contains thousands of bioactive molecules that orchestrate a variety of metabolic and signaling processes in health and disease, comprising a natural combination approach.
  • Although food composition varies widely, cumulative evidence suggests that specific dietary macronutrients and micronutrients can affect biological processes involved in NAFLD pathogenesis.